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- Proton therapy is a very promising type of external radiotherapy that is not yet used as its full potential because of its high sensitivity to errors. Especially, as the treatment is usually delivered in a fractionated way, it is sensitive to the patient inter-fraction motion. Ideally, the treatment plan should therefore be adapted before every treatment session. However, regular treatment planning is cumbersome and is subject to tedious quality assurance protocols in order to be accepted by the physician and physicist in charge. In this thesis, we propose and test a strategy for replanning in real time a proton therapy treatment plan. The goal is for the adapted plan to preserve the quality and robustness of the initial plan.