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Characterization of poly (2,2,6,6-tetramethylpiperidin-4-yl methacrylathe)-r-(oligoethyleneglycol methacrylate) hydrogel prepared by free radical polymerization

Storme, Yannick
(2018)

Files

Storme_81191200_2018.pdf
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Details

Supervisors
Gohy, Jean-François ; Dupont, Christine
Faculty
Faculté des bioingénieurs
Degree label
Master [120] : bioingénieur en chimie et bioindustries
Abstract
Due to their exceptional abilities, hydrogels are widely studied for applications in medicine or environmental decontamination. The possibility to make hydrogel intelligent materials in addition to bio-compatibility and swelling capacity make them very promising candidates for practical use in drug delivery. The aim of this master thesis is the study of the impact of the crosslinker amount and of the ratio of comonomers on the mechanical and chemical properties of hydrogel composed of 2,2’,6,’6-tetramethyl-1-piperidinyloxy methacrylate (PTMA) and poly(ethylene glycol) methyl ether methacrylate (OEGMA). A wide range of crosslinker and comonomers ratios is tested to determine the limits of this well know reaction and provide information about the physico-chemical behaviour of the formed hydrogel. Nuclear magnetic resonance, swelling tests, cyclic voltammetry and rheology are used to characterise the accordingly formed P(TMA-r-OEGMA) hydrogel. These techniques show that those gels exhibit promising characteristics that could be tested for future work in the field of drug delivery.