Enhancing ultracentrifugation efficiency in GSK's Hepatitis B virus vaccine purification unit through minimization of rotor losses

Details

Supervisors

Luis Alconero, Patricia ; Maquet, Sebastien

Faculty

Ecole polytechnique de Louvain

Degree label

Master [120] : ingénieur civil en chimie et science des matériaux, à finalité spécialisée

Abstract

This master's thesis investigates the critical issue of rotor loss in the Hepatitis B Vaccine (HBV) production process at GlaxoSmithKline (GSK), a prominent global pharmaceutical company. The study centers on the intricate stage involving centrifuge rotors, pivotal for the separation and refinement of HBV from a complex mixture of cells and proteins. Rotor loss, stemming from wear, corrosion, misalignment, or insufficient maintenance, poses significant challenges, including operational disruptions, increased costs, and safety concerns. The thesis aims to comprehensively explore the causes, consequences, and implications of rotor loss, employing a multidisciplinary approach encompassing engineering, biotechnology, management, economics, and societal perspectives. The research strives to provide a holistic understanding of the issue, proposing innovative strategies and best practices to mitigate rotor loss, optimize the HBV production process, and elevate overall operational excellence at GSK. The significance of this research extends beyond GSK, addressing a prevalent challenge in the broader pharmaceutical industry involved in biopharmaceutical production. By presenting effective solutions, the thesis contributes to the industry's pursuit of heightened operational reliability, cost-effectiveness, and product quality.