L'impact de la vitamine K1 et K2 sur la maladie de l'ostéoporose

Details

Supervisors

Devogelaer, Jean-Pierre ; Boutsen, Yves

Faculty

Faculté de pharmacie et des sciences biomédicales

Degree label

Master [120] en sciences pharmaceutiques, à finalité spécialisée

Abstract

Osteoporosis has become a real public health problem in Belgium and its prevalence increases with age. It is a systemic skeletal disease characterized by a reduction in bone mass and a qualitative and quantitative deterioration of the microarchitecture of bone tissue. This deterioration makes the bones more fragile and increases the risk of fractures. These fractures can be life changing, cause pain and loss of independence. Therefore, it is important to prevent osteoporosis. In recent years there has been growing suspicion that vitamin K plays an important role in bone microarchitecture. Scientists have been investigating the addition of vitamin K in the prevention and treatment of osteoporosis. To date, there are several studies that have evaluated the impact of vitamin K on the disease of osteoporosis. This paper is divided into two parts. The first part presents the general aspects of vitamin K and osteoporosis. In the second part, several studies are reviewed concerning the association between vitamin K and fracture risk, bone mineral density or remodeling markers. The different results are discussed and compared with each other to draw a conclusion if there is a statistically significant association between vitamin K and osteoporosis disease.