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Impression 3D de comprimés médicaux pour le traitement personnalisé des patients

Thomaes, Enola
(2024)

Files

Thomaes_91802100_2024.pdf
  • Embargoed access until 2025-07-01
  • Adobe PDF
  • 2.73 MB

Details

Supervisors
Jonas, Alain M. ; des Rieux, Anne
Faculty
Ecole polytechnique de Louvain
Degree label
Master [120] : ingénieur civil biomédical, à finalité spécialisée
Abstract
enThis thesis investigates the application of 3D printing in pharmaceutical manufacturing, with a particular focus on implementing polymer/aspirin blends using the Fused Deposition Modeling (FDM) method. Throughout various research phases, a protocol has been developed to produce PCL filaments loaded with 20% and 30% aspirin, making them suitable for FDM printing and enabling the fabrication of pharmaceutical tablets. Characterization analyses, such as Fourier-transform infrared spectroscopy and atomic force microscopy, indicate a uniform distribution of aspirin in the tablets. The release kinetics of the active ingredient exhibit a burst release phenomenon followed by a slower phase The dissolution rate is influenced by the environment and the initial concentration of aspirin, being more effective in the gastric milieu, with 74% of the aspirin in the 20% loaded tablets released over 4 hours. In conclusion, this study highlights the potential of 3D printing in personalized medicine manufacturing. Although there are avenues for future research to further refine this method and address the specific needs of patients, these results offer promising prospects for the future of personalized medicine.