Synthesize an evidence-based approach for the evaluation of phytotherapeutics: A systematic application on Hawthorn

Details

Supervisors

Dujardin, Nathalie ; Rocour, Muriel

Faculty

Faculté de pharmacie et des sciences biomédicales

Degree label

Master [120] en sciences pharmaceutiques

Abstract

Cardiovascular diseases are a global public health concern. This concern is more urgent in case of drug shortages like in the Syrian war where many people start to depend on Phytotherapy for prevention and treatment. Unfortunately, many uncertainties lie ahead about the plants clinical efficacity and security. More complicating the problem is the absence of an approach that clarifies where, how and what information the clinician can evaluate before arriving at better positioning the plants usage clinically, and optimize his recommendation. In this dissertation, an evidence-based approach is synthesized in visual forms of outlines, figures and tables using today’s sources and directions of international guidelines to overcome the confusion about this topic, and better address the urgent need of phytotherapeutics beyond only the personal experience or the traditional claims. This approach is tested then on a most naturally-cultivated used plant for a cardiovascular claim in Syria, Hawthorn. A systematic search is monitored concerning a special extract of Hawthorn WS 1442. The records of the search are synthesized, then critically appraised to estimate a benefit/risk ratio, and confirm or revoke Hawthorn potential role in the different categories of heart failure in the light of its current therapeutic objectives. This aspires to help pharmacists and other medical practitioners in Syria at reviving their clinical spirits for estimating other benefit/risk ratios of other traditional plants and take a step forward the patient-centered care.