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Developing a Chiral Resolution of Mandelic Acid through Preferential Cocrystallization

Caro Garrido, Camila
(2020)

Files

Caro_Garrido_38551400_2020.pdf
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  • Adobe PDF
  • 3.17 MB
Caro_Garrido_38551400_2020_Annexe1.pdf
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  • Adobe PDF
  • 1.33 MB

Details

Supervisors
Leyssens, Tom
Faculty
Faculté des sciences
Degree label
Master [120] en sciences chimiques
Abstract
The cocrystal conglomerate constituted of two active pharmaceutical ingredients, chiral mandelic acid and achiral Nefiracetam, was successfully used for the preferential crystallization of mandelic acid in acetonitrile using single and coupled containers. Our research demonstrates that exceptional high purity values can be achieved. These results emphasize the application of preferential crystallization to the resolution of cocrystal conglomerate systems.