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Effect of polyphenol on bone properties of different parts of axial and appendicular skeleton in osteogenesis imperfecta mice (OIM)

Van Driessche, Martin
(2024)

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VanDriessche_Martin_04561501_2023-2024.pdf
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Details

Supervisors
André, Grégoire
Faculty
Faculté des sciences de la motricité
Degree label
Master [60] en kinésithérapie et réadaptation
Abstract
Osteogenesis imperfecta (OI) is a rare genetic disorder of connective tissue, most commonly caused by an abnormality in type 1 collagen. The aim of the study was to examine the effects of a flavonoid (molecule-C) on the number of fractures, mechanical tests, bone parameters, and new bone apposition of various parts of the axial and appendicular skeleton in mice with osteogenesis imperfecta (oim/oim). Two groups of mice, aged 17 to 23 weeks were used, divided into wild-type (WT) (n=30) and osteogenesis imperfecta (OI) (n=79) subgroups receiving varying and intermittent doses of molecule-C for the treated groups. The results showed a significant reduction in the incidence of new fractures in treated OIM mice, suggesting a potential dose-dependent effect. Significant differences were observed in vertebral resistance to compression tests between wild-type and OIM mice. No significant improvement was observed in the mechanical properties of femurs, but there was a potential dose effect by molecule-C. Analyses of bone parameters of caudal vertebrae and tibiae revealed several significant differences in bone densitometric parameters between WT and OIM groups with some significant improvements noted, depending on the bone site (cortical or trabecular). It would be interesting in the future to conduct further research on the dose effect over longer periods to verify the potential effects of molecule-C in mice with osteogenesis imperfecta.