The role of radiotherapy in the treatment of uterine sarcomas

Details

Supervisors

Marbaix, Etienne

Faculty

Faculté de médecine et médecine dentaire

Degree label

Master [180] en médecine

Abstract

Backround:Uterine sarcomas are rare and aggressive neoplasms, representing 3-9% of all uterine malignancies and have a worse prognosis than carcinomas.The aim of this study is to determine the efficiency of radiotherapy in the treatment of these tumors, as the adjuvant therapy is a very debated clinical issue. Given the rarity of these tumors, there haven’t been many randomised studies. Methods and materials: This is a retrospective study including 68 patients presenting one of the following sarcomas : leiomyosarcom, endometrial stromal sarcoma and carcinosarcoma. These women have been treated at the Cliniques Universitaires St Luc from January 2000 to April 2017. The data was collected through the DIAMIC, DaVINCI and ANA databases. The results were analysed via Kaplan Meier curves to determine the effects of radiotherapy versus other adjuvant treatments. Results: 68 patients were included in this study, 50% had carcinosarcoma, 22% leiomyosarcoma and 28% endometrial stromal sarcoma. 4 of them had radiotherapy alone and 10 combined with chemotherapy. The median of age was 69,8 years and 38% had stage FIGO I,5,5% FIGO II 24,5% FIGO III, 22% FIGO IV desease at the time of the diagnosis. Conclusion: Radiotherpy alone did not show any overall survival with 1 of the patients dying and 2 of them showing distant metastases. Neither did the combination with the chemotherapy. But there is a selection bias since the patients who benefited adjuvant therapy had advanced stage desease (39% had FIGO stage III and 54% FIGO stage IV). Thus furthermore investigations are needed.