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Study of the interplay between BAR domain proteins and actin polymerization around membrane deformations

Coster, Charlotte
(2021)

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Coster_59821600_2021_Annexes.pdf
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Coster_59821600_2021.pdf
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Details

Supervisors
Morsomme, Pierre
Faculty
Faculté des bioingénieurs
Degree label
Master [120] : bioingénieur en chimie et bioindustries, à finalité spécialisée
Abstract
Bin/Amphyphysin/Rvs (BAR) domain proteins are a diverse superfamily of proteins having a common denominator; they sense and/or induce membrane curvatures. Over the past couple of years, they have been of particle interest in research studying cellular processes implicating membrane deformations, such as endocytosis, cell migration and actin regulation. In addition, their ability to sense or induce membrane curvature makes them noteworthy candidates as translators of mechanical stimuli into biochemical signals mediated by actin polymerization. Yet, few specific molecular mechanisms involving BAR domain protein and the actin cytoskeleton are understood. In this work, relating topologically induced membrane curvature to actin polymerization events was of particular interest. Firstly, it was wondered if specific BAR domain proteins ...