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Hybrid catalysis for stereoselective ketone reduction

Doutry, Aurélien
(2023)

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Doutry_13111800_2023.pdf
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Details

Supervisors
Debecker, Damien P.
Faculty
Faculté des bioingénieurs
Degree label
Master [120] : bioingénieur en chimie et bioindustries, à finalité spécialisée
Abstract
Production of chiral alcohol in the pharmaceutical industry has a huge impact on the environment. The utilization of current homogeneous catalysts for asymmetric reduction generates wasted chemicals for the synthesis of the catalyst and post purification of the pharmaceutical’s drugs. Moreover, for the reduction of ketones to chiral alcohol, stoichiometric concentration of NADH needs to be provided. The combination of an active metal for the regeneration of NADH and an enzyme for the synthesis of chiral alcohol is impossible because there is a mutual inactivation. New catalysts with the heterogenization of a metal active and an enzyme appear to be the future generation of catalysts.